Calcified Brain Metastases from Ovarian Cancer* Brain metastases from ovarian cancer

A 65-yearold woman with no known malignancy had lower extremity swelling, fever, and weakness of the left extremity. She gave a history of multiple trips to Mexico. Plain and enhanced head CT scans showed multiple calcified enhancing lesions located throughout the brain parenchyma (Fig. 1). The presumptive diagnosis was infectious disease, such as tuberculosis, fungal infection, or cysticercosis. However, further workup, including serum titers for cysticercosis , was negative for an infectious disease. Approximately 3 months later, axillary and subcutaneous nodules developed. Biopsy of these lesions showed metastatic grade-IV adenocarcinoma with psammomatous calcifications and papillary features most consistent with an ovarian primary tumor. Clinical and CT examination of the pelvis showed a large adnexal mass, and the disease, such as tuberculosis, fungal infection, or cysticercosis. However, further workup, including serum titers for cysticercosis, was negative for an infectious disease.